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Effects of subchronic treatment with cis-platinum on testicular function, fertility, pregnancy outcome, and progeny
Fertility cis-platinum pregnancy outcome progeny
2009/2/10
Cis-platinum-based chemotherapy is known to impair spermatogenesis, but the effects of paternal cis-platinum treatment on the progeny are unknown. To study this effect, sexually mature male Sprague-...
Effects of the Chemotherapeutic Agents for Non-Hodgkin Lymphoma, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone（CHOP）, on the Male Rat Reproductive System and Progeny Outcome
Anticancer drugs spermatogenesis male germ cell apoptosis adverse effects developmental toxicity
2008/12/24
Chemotherapy of non-Hodgkin lymphoma (NHL) with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) is associated with significant gonadal damage. Our goal was to determine the impact ...
The Analysis of Meiotic Segregation Patterns and Aneuploidy in the Spermatozoa of Father and Son With Translocation t（4;5）（p15.1;p12）and the Prediction of the Individual Probability Rate for Unbalanced Progeny at Birth
FISH risk assessment
2008/12/24
Reciprocal chromosomal translocations (RCT) have long been recognized as important etiological factors in reproductive failure. In the present study, the meiotic segregation patterns of the sperm...