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长三角药物高等研究院举行2021开学典礼暨第二届Delta论坛(图)
中国科学院 长三角 Delta论坛
2023/7/11
2021年12月11日上午,长三角药物高等研究院(以下简称长高院)2021级新生开学典礼在江苏省南通市海门科技园举行。南通市海门区政府领导、合作高校领导、长高院领导和2021级新生合计200人现场参会。开学典礼线上直播吸引超过3,000人在线观看。
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我国在新冠肺炎疫情控制1年多后,在2021年5月21日,广州再次出现了新冠肺炎的本土病例。本次疫情是全球流行的Delta变异株,与以往的新冠肺炎病毒不同的是Delta变异毒株传播力更加强,而且潜伏期短,在感染者体内的病毒载量远高于前期的新冠肺炎病毒。面临Delta变异毒株的严重威胁,这引起了省、市新冠肺炎疫情防控组的高度重视。
建立一种基于半胱氨酸偶联方式的抗体偶联药物抗Delta样蛋白3(DLL3)单抗-MPVP-PBD的质控方法。方法 本实验利用转基因细胞法,以转染了DLL3的HEK 293T细胞系为靶细胞测定抗DLL3单抗-MPVP-PBD的生物学活性;利用ELISA法测定结合活性;利用CE-SDS和SEC-UPLC测定大小异质性;利用iCIEF分析电荷异质性;分别利用HIC-HPLC和LC-MS对药物抗体偶联比(...
通过临床和影像学随访,观察比较陶瓷-陶瓷(Delta陶瓷界面)与陶瓷-高交联聚乙烯界面在治疗髋关节疾病的短期临床疗效。方法 回顾分析自2015年7月至2016年7月共65例(73髋)运用陶瓷对陶瓷(Delta陶瓷界面)和陶瓷对高交联聚乙烯生物型假体行初次全髋关节置换术患者的临床资料,根据关节摩擦界面配伍类型分为两组,即陶瓷对陶瓷组(CC组)和陶瓷对聚乙烯组(CP组)。对有效随访的患者通过X线片测...
Gamma delta T 细胞及其抗肿瘤研究的进展
γδ T细胞 免疫治疗 肿瘤
2014/6/5
Gamma delta(γδ)T细胞表达Vγ9Vδ2 T细胞受体,占外周血T淋巴细胞的2%~5%左右,主要分布于黏膜相关淋巴组织,是T细胞的亚群之一。其免疫作用介于固有免疫和适应性免疫之间,为主要组织相容性复合体(MHC)非限制性细胞, 具有一定的非特异性杀伤肿瘤细胞的作用,并且具有广泛的抗瘤谱。许多研究证实γδ T细胞参与了机体免疫防御系统的第一道防线,未来以γδ T细胞为基础的细胞免疫疗法,将...
观察佐剂关节炎(AA)大鼠肺功能、肺组织Notch信号通路的变化,探讨AA大鼠肺功能降低的机制。 方法:将30只大鼠随机分为正常组和模型组,每组15只,向模型组大鼠右后足跖皮内注射弗氏完全佐剂0.1 mL致 炎,复制成AA模型。致炎30 d后,观察两组大鼠足跖肿胀度、关节炎指数、肺功能、肺病理形态学及肺组织Notch受 体/配体表达的变化。结果:与正常组相比,模型组大鼠足跖肿胀度、关节炎指数、肺功...
上调Delta-Like1基因可增强
小细胞肺癌化疗敏感性
DLL1 多药耐药 肺肿瘤
2013/12/4
背景与目的 DLL1(Delta-Like1)与Notch受体结合激活Notch信号通路,从而决定细胞的分化,并调控多种组织的生长发育。已有研究报道DLL1与肿瘤的生长、分化密切相关。前期基因芯片发现DLL1与小细胞肺癌的耐药性相关,本研究旨在进一步探讨DLL1在小细胞肺癌多药耐药中的作用。方法 首先通过QRT-PCR和Western blot从基因和蛋白水平检测化疗敏感细胞株H69及多药耐药细胞...
Cervical cancer screening among female undergraduates and staff in the Niger delta region of Nigeria
Knowledge Cervical Cancer Risk Factors Screening Niger Delta
2013/1/31
A significant decrease in the incidence of cervical cancer and mortality is expected when all eligible women have access to regular Screening tests. Factors that can influence participation rate inclu...
Anthropogenic Indices of Soil-Transmitted Helminthiasis among Children in Delta State, Southern Nigeria
Soil transmitted helminthiasis School Children Nigeria
2009/11/26
Background: The prevalence and intensity of soil-transmitted helminth infections and the anthropogenic risk factors of 978 randomly selected primary school children from Igbede community in Isoko...
Clinical and Laboratory Correlates of Frontal Intermittent Rhythmic Delta Activity (FIRDA)
FIRDA EEG clinical findings metabolic disturbances
2009/6/26
This study was carried out to determine whether certain clinical, laboratory, or radiological parameters predispose patients to develop FIRDA in acute situations. Charts of patients in whom FIRDA was ...
Widely-distributed arsenic pollution in groundwater in the Red River Delta, Vietnam
Arsenic Groundwater Human urine Red River Delta Vietnam
2009/4/1
High As concentrations over the World Health Organization (WHO) drinking water guideline were recently found in groundwater of Gia Lam District and Thanh Tri District, Hanoi, located in the center of ...
The effect of delta 9-tetrahydrocannabinol in utero exposure on rat offspring fertility and ventral prostate gland morphology
marihuana testes ventral prostate gland testosterone
2009/2/23
Male rats exposed in utero to delta 9-tetrahydrocannabinol (delta 9-THC) had lower levels of testosterone (T) and luteinizing hormone (LH) prior to puberty (P less than 0.01). At puberty, the levels...
Ontogeny of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase(3 beta-HSD)in human testis as studied by immunocytochemistry
Ontogeny 3ı -hydroxysteroid dehydrogenase/iı -iS.” isomerase human testis immunocytochemistry
2009/2/7
The enzyme complex 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) is involved in the biosynthesis of all classes of active steroids, including androgens. To correl...
目的: 研究Delta-like 4(DLL4)在胃癌中的表达及其与血管生成的关系. 方法: 采用免疫组化EnVision法检测胃癌组织芯片中DLL4的表达, 用CD34进行微血管内皮细胞染色, 计算微血管密度(MVD), 分析其相关性. 结果: DLL4在胃癌中的表达明显高于正常胃黏膜(85.9% vs 35.3%, P<0.01). DLL4的高表达与胃癌的转移(r = 0.612, P<0....
Differential expression of CCAAT/enhancer-binding protein-delta(c/EBPdelta)in rat androgen-dependent tissues and human prostate cancer
CCAAT/enhancer-binding protein-delta(c/EBPdelta) rat androgen-dependent tissues human prostate cancer
2008/12/26
CCAAT/enhancer-binding protein delta (C/EBPdelta) is a nuclear transcription factor that regulates cellular growth and differentiation. In this study we demonstrate that C/EBPdelta gene expression i...