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Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-alpha in the Rat
cyclooxygenase-2 COX-2 COX-1 prostaglandin E2 neuroinflammation blood-brain barrier ischemia stroke matrix metalloproteinase MMP-3 MMP-9 gelatinase B stromelysin-1 oxidative stress indomethacin cyclooxygenase-1 glutathione free radicals MRI
2015/7/29
Increased permeability of the blood-brain barrier (BBB) is important in neurological disorders. Neuroinflammation is associated with increased BBB breakdown and brain injury. Tumor necrosis factor-alp...
Brain tumours: Successes and challenges on the other side of the blood-brain barrier
Brain tumours the blood-brain barrier cancers
2015/4/21
Tumours of the central nervous system encompass a large variety of cancers, ranging from slow-growing to rapidly progressive. Although comparatively rare in adults, central nervous system malignancies...
Breaching the Blood-Brain Barrier as a Gate to Psychiatric Disorder
Blood-Brain Barrier Psychiatric Disorder
2009/9/3
The mechanisms underlying the development and progression of psychiatric illnesses are only partially known. Clinical data suggest blood-brain barrier (BBB) breakdown and inflammation are involved in ...
Increased blood-brain barrier permeability to tetracycline in rabbits under dysbaric conditions
decompression tetracycline permeability rabbits
2009/7/17
Alteration of the blood-brain barrier (BBB) by dysbaric exposure may have relevance in several areas of hyperbaric medicine. Drugs administered to persons exposed to dysbaric conditions, e.g., divers,...
Changes in blood-brain barrier permeability to drugs in decompressed rats
decompression human blood brain barrier animal rat drug
2009/7/16
A study has been made of changes in permeability of the blood-brain barrier (BBB) to drugs following exposure to compression-decompression. Fifty-five rats were exposed to 6.1 b (abs) air for 90 min a...
Microbubble damage to the blood-brain barrier: relevance to decompression sickness
decompression pulmonary blood brain barrier bubbles animal Guinea Pigs
2009/7/8
Decompression sickness affecting the nervous system is still a serious problem in diving, but the mechanisms involved are in dispute. Although microbubbles can be detected in the pulmonary artery on d...
Reversibility in blood-brain barrier, microcirculation, and histology in rat brain after decompression
decompressio air animal rat
2009/6/8
To examine the changes in blood-brain barrier (BBB), cerebral microcirculation, and histology from 15 min to 72 h after decompression, 90 rats were exposed to experimental compression to 6 atm abs air...
Effect of anti-C5a antibody on blood-lung and blood-brain barrier in rabbits after decompression
decompression pulmonary complement rabbit animal
2009/6/8
The complement activation product C5a may be an important mediator of tissue injury after decompression stress. This study investigated whether the administration of anti-C5a antibody may reduce chang...
The effect of air bubbles on rabbit blood brain barrier
animal Rabbit Blood-Brain Barrier drug effects Brain drug effects
2009/6/5
Several investigators have claimed that the blood brain barrier (BBB) may be broken by circulating bubbles, resulting in brain tissue edema. The aim of this study was to examine the effect of air bubb...
Microbubble damage to the blood-brain barrier: relevance to decompression sickness
decompression pulmonary blood brain barrier bubbles animal Guinea Pigs
2009/3/25
Decompression sickness affecting the nervous system is still a serious problem in diving, but the mechanisms involved are in dispute. Although microbubbles can be detected in the pulmonary artery on ...