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研究左旋龙脑对中波紫外线（UVB）照射后小鼠皮肤光损伤的影响。方法：通过UVB照射Balb/c小鼠建立光损伤模型，创面外用左旋龙脑，每天1次，连续给药11 d；在伤后不同时相点取材，HE染色观察皮肤组织的病理变化，对皮肤红斑、水肿反应进行评分；测定左旋龙脑对创面愈合时间、组织含水量、8 OHdG、IL 6和NF κB的影响。结果：与正常组相比，光损伤小鼠红斑、水肿指数明显增加；与模型组相比，左旋龙...
THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ANTAGONIST, GW9662, ALTERS UVB-INDUCED INFLAMMATORY RESPONSES, APOPTOSIS, AND DELAYED HYPERPROLIFERATION
PPARγ UVB COX-2
2015/1/28
It has recently been shown that the gamma subtype of the peroxisome proliferator-activated receptor (PPARγ) is a target of ultraviolet B (290-320 nm; UVB) irradiation, and that PPARγ activation is nec...
THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ANTAGONIST, GW9662, ALTERS UVB-INDUCED INFLAMMATORY RESPONSES, APOPTOSIS, AND DELAYED HYPERPROLIFERATION
PPARγ UVB COX-2
2015/1/19
It has recently been shown that the gamma subtype of the peroxisome proliferator-activated receptor (PPARγ) is a target of ultraviolet B (290-320 nm; UVB) irradiation, and that PPARγ activation is nec...
考察槲皮素、虎杖苷、染料木素的抗氧化能力及对中波紫外线(UVB)致永生化人角质形成细胞(HaCaT)损伤的保护作用。方法 以维生素C为阳性对照药，通过DPPH自由基清除实验，羟基(·OH)自由基清除实验，测定槲皮素、虎杖苷、染料木素不同浓度的抗氧化能力。体外培养HaCaT细胞，与槲皮素、虎杖苷、染料木素100 μmol/L共抚育30 mim后，以30 mJ/cm2 UVB直接照射细胞，12 h后收...