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Although only 10 percent of amyotrophic lateral sclerosis (ALS) cases are hereditary, a significant number of them are caused by mutations that affect proteins that bind RNA, a type of genetic materia...
Incorporation of urea and ammonia nitrogen into ileal and fecal microbial proteins and plasma free amino acids in normal men and ileostomates
Ammonia urea nitrogen metabolism
2016/6/2
The importance of urea nitrogen reutilization in
the amino acid economy of the host remains to be clarified.
Lipoprotein(a) and dietary proteins: casein lowers lipoprotein(a) concentrations as compared with soy protein
soy protein casein liquid-formula diets
2016/5/30
Substitution of soy protein for casein in the diet
decreases LDL cholesterol and increases HDL cholesterol. How
the 2 proteins affect lipoprotein(a) [Lp(a)], an independent risk
factor for coronary...
Expression of Heat Shock Proteins (HSPs) in Aged Skeletal Muscles Depends on the Frequency and Duration of Exercise Training
Aging multiple short-duration exercise training single long-duration exercise training heat shock protein
2015/8/28
However, the associated molecular mechanisms mediating
different types of exercise training-induced adaptations are not
yet completely understood. Therefore, the purpose of this study
was to inv...
Determination and Correlation of Anticardiolipin Antibody with High Sensitivity C- reactive Proteins and its Role in Predicting Short Term Outcome in Patients with Acute Coronary Syndrome
Acute coronary syndrome Anticardiolipin antibodies
2015/7/22
Anticardiolipin antibody (aCL) is considered to be an independent risk factor while high sensitivity C reactive protein (hsCRP) is an established marker for coronary artery disease. This study was con...
Bioinformatics Analysis and Annotation of Microtubule Binding and Associated Proteins (MAPs) - Creating a Database of MAPs
Microtubule Binding Associated Proteins
2015/5/26
Microtubules have many roles in the cytoskeletal infrastructure. This infrastructure underlies vital processes of cellular life such as motility, division, morphology, and intracellular organization a...
IDENTIFICATION OF NOVEL SMALL MOLECULE INHIBITORS OF PROTEINS REQUIRED FOR GENOMIC MAINTENANCE AND STABILITY
RPA cancer DNA repair
2015/5/25
Targeting uncontrolled cell proliferation and resistance to DNA damaging chemotherapeutics using small molecule inhibitors of proteins involved in these pathways has significant potential in cancer tr...
Exercise Training-Induced Changes in Inflammatory Mediators and Heat Shock Proteins in Young Tennis Players
Hydrogen peroxide cytokines Hsp27 Hsp70 overreaching
2015/5/15
Heat shock proteins (Hsp) represent proteins’ groups, whose protective function, may be induced by heat, reactive oxygen species, cytokines etc. We evaluated blood levels of Hsp27 and Hsp70, and their...
Dissecting the expression landscape of RNA-binding proteins in human cancers
RNA-binding proteins cancer pathogenesis
2015/3/5
Background RNA-binding proteins (RBPs) play important roles in cellular homeostasis by controlling gene expression at the post-transcriptional level. Results We explore the expression of more than 800...
DNA Repair Proteins as Molecular Targets for Cancer Therapeutics
DNA repair cancer therapeutics
2014/12/12
Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle and current treatment...
Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation
Ape1 inhibitor base excision repair biomarkers
2014/12/12
There has been a recent upsurge in the development of small-molecule inhibitors specific to DNA repair proteins or proteins peripherally involved in base excision repair and the DNA damage response. T...
Small-Molecule Hydrophobic Tagging Induced Degradation of HaloTag Fusion Proteins
Degradation of HaloTag Fusion Proteins Small-Molecule Hydrophobic Tagging
2014/11/25
The ability to regulate any protein of interest in living systems with small molecules remains a challenge. We hypothesized that appending a hydrophobic moiety to the surface of a protein would mimic ...
HOUSTON – (Jan. 22, 2014) – Rice University scientists have created a way to fine tune a process critical to the pharmaceutical industry that could save a lot of time and money.
Molecular Analyses of Early-Onset Gastric Cancer in Brazilian Patients: TP53 Mutations, Cadherin-Catenin and Mucins Proteins Expression
Early-Onset Gastric Cancer Young Patients Cellular Adhesion TP53 Mutations
2013/1/29
Early gastric carcinomas may develop with a molecular profile differing from sporadic carcinomas occurring at a later age. In this study, we analyzed a retrospective series of 88 patients with gastric...
Favorable and unfavorable amino acid residues in water-soluble and transmembrane proteins
Amino Acid Composition Nucleotide Composition Favorable and Unfavorable Residues Water-Soluble and Transmembrane Proteins Thermophilic and Mesophilic Species
2013/1/28
We analyzed the amino acid residues present in the water-soluble and transmembrane proteins of 6 thermophilic and 6 mesophilic species of the domains Archaea and Eubacteria, and characterized them as ...