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Anthocyanins are absorbed in glycated forms in elderly women: a pharmacokinetic study
Anthocyanins flavonoids antioxidants
2016/6/13
Anthocyanins are potent antioxidants that are
widely distributed in fruit, vegetables, and red wines. Anthocyanin
products are also prescribed as medicines in many countries
for treating various di...
Mining Biomedical Literature to Extract Pharmacokinetic Drug-Drug Interactions
Machine Learning Pharmacokinetics Information Extraction
2015/5/26
Polypharmacy is a general clinical practice, there is a high chance that multiple administered drugs will interfere with each other, such phenomenon is called drug-drug interaction (DDI). DDI occurs w...
Pharmacokinetic Prediction of Levofloxacin Accumulation in Tissue and Its Association to Tendinopathy
Monte Carlo Simulation Tendon Incidents Levofloxacin Pharmacokinetic
2013/2/19
Objectives: We investigated pharmacokinetic tissue distributions of Levofloxacin to explain adverse tendon incidents. Methods: The pharmacokinetic profiles of single and multiple dosing of 500 mg Levo...
Pharmacokinetic behavior of Amikacin in 31 Iranian critically ill septic patients
Amikacin Sepsis Critically ill patient ICU
2010/1/6
The pharmacokinetic behavior of amikacin and predictive performance of Sawchuk-Zaske dosing method, have been prospectively evaluated in 31 (16 male, 15 female) critically ill septic patients of mean ...
The relationship between pharmacokinetic variables and pharmacodynamic profiles of bolus versus continuous infusion of furosemide in critically ill patients
Furosemide Pharmacokinetics Pharmacodynamic Bolus Infusion
2010/1/5
In this investigation, the pharmacokinetic variables of continuous infusion and intermittent bolus injection of furosemide and the possible relationship between its pharmacokinetic characteristics and...
PHARMACOKINETIC COMPARISON BETWEEN REGULAR INSULIN AND ORAL INSULIN BASED ON SUPERPOROUS HYDROGEL POLYMERS IN HEALTHY VOLUNTEERS
C–peptide Oral insulin SPH SPHC
2009/12/30
Background: All contemporary methods of insulin administration are non-physiological. Insulin is not absorbed from the gastrointestinal tract because of its peptide nature. The aim of the present stud...
A rapid and sensitive HPLC method for the analysis of celecoxib in human plasma:application to pharmacokinetic studies
Celecoxib HPLC Pharmacokinetics Human Plasma
2009/12/18
Background and the purpose of the study: A suitable high-performance liquid chromatography (HPLC) method for determination of celecoxib levels in plasma is of prime need for the pharmacokinetics and b...
A pharmacokinetic study of injectable testosterone undecanoate in hypogonadal men
Testosterone LH FSH estrogen SHBG
2009/2/18
Testosterone undecanoate (TU) provides testosterone (T) replacement for hypogonadal men when administered orally but requires multiple doses per day and produces widely variable serum T levels. We i...
Oral Testosterone in Oil：Pharmacokinetic Effects of 5 Reduction by Finasteride or Dutasteride and Food Intake in Men
Androgen hypogonadism metabolism acyline
2008/12/23
Oral administration of 400 mg of testosterone (T) in oil, when combined with the 5 reductase inhibitor dutasteride (D), elevates serum T in medically castrated men to the normal range. In this study...
Estimation of Pharmacokinetic Parameters Based on the Patient-Adjusted Population Data
population pharmacokinetics pharmacokinetics clearance volume of distribution half life
2018/4/19
Population pharmacokinetic data, adjusted for patient characteristics, are recommended for the design of initial dosage regimens of some therapeutically monitored drugs in patients for whom patient-sp...
A rapid and sensitive HPLC method for the analysis of metronidazole in human plasma: application to single dose pharmacokinetic and bioequivalence studies
Metronidazole HPLC Pharmacokinetics Bioavailability
2010/2/4
A sensitive, accurate and rapid reverse phase HPLC method was developed to quantitate plasma levels of metronidazole in order to conduct a comparative bioavailability studies. The drug and internal st...
The Relationship Among Pharmacokinetic Parameters: Effects of Altered Kinetics on the Drug Plasma Concentration-Time Profiles
pharmacokinetics clearance volume of distribution elimination half-life elimination rate constant
2018/3/22
The learning tools used by this instructor in a pharmacokinetics course offered to entry level PharmD students are presented for the topic of relationship among pharmacokinetic parameters. These tools...
On-Line, Individualized, and Interactive Pharmacokinetic Scenarios with Immediate Grading and Feedback and Potential for Use by Multiple Instructors
Individualized Interactive Pharmacokinetic Scenarios Immediate Grading Feedback Potential Multiple Instructors
2016/3/15
On-line (web-based) pharmacokinetic modules were developed for 25 topics in basic and clinical phar-macokinetics. The modules consist of spreadsheet files, relational databases, and dynamic web. Instr...
Pharmacokinetic Simulations Using Cellular Automata in a Pharmacokinetics Course
Pharmacokinetic Simulations Cellular Automata Pharmacokinetics Course
2016/3/14
Cellular automata are systems composed of two-dimensional cell arrays which change according to specific, pre-determined rules. For this reason, cellular automata were used to illustrate and simulate ...
Development and Evaluation of an Interactive Internet-Based Pharmacokinetic Teaching Module
Development Evaluation Interactive Pharmacokinetic Module
2016/3/14
An internet-based pharmacokinetic teaching module has been developed. This module is interactive, learnercentered, asynchronous, and requires minimal computer knowledge to operate. The main components...