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Optimized Conditions for the Delivery of Small Membrane Impermeable Compounds into Human Cells Using Hypotonic Shift
Hypotonic Shift Cell-Based Assay Membrane Impermeable Compound Delivery Osmolarity Endocytosis
2013/1/29
Cell-based assays represent a major end point of high throughput screening (HTS) but a key limitation of such assays is the potentially poor membrane permeability of test compounds. In this study, we ...