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浙江大学生命科学研究院黄俊实验室在Nature Communications发表论文阐述乳腺癌易感基因BRCA2维持基因组稳定性的新机制（图）
浙江大学生命科学研究院 黄俊实验室 乳腺癌 易感基因 BRCA2 基因组
2017/11/14
2017年11月13日，生研院黄俊实验室在Nature Communications发表了题为“BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability”的研究论文，阐述了乳腺癌易感基因BRCA2维持基因组稳定性的新机制。
Plasma folate, vitamin B-6, and vitamin B-12 and breast cancer risk in BRCA1- and BRCA2-mutation carriers: a prospective study
BRCA BRCA1 BRCA2 breast cancer B vitamins epidemiology folate hereditary breast cancer vitamin B-6 vitamin B-12
2018/12/14
Background: B vitamins [vitamins B-6, B-9 (folate), and B-12] play important roles in nucleotide biosynthesis and biological methylation reactions, aberrancies of which have all been implicated in car...
分析中国新疆多民族地区的高风险遗传性乳腺癌BRCA1/2 基因突变位点情况。方法：以2009年1 月到2010年12月新疆医科大学附属肿瘤医院收治的来自新疆地区的68例符合高风险遗传性乳腺癌标准的患者为研究对象，其中HBC 12例，HBOC 4 例，E-BC 25例，BI-BC 10例，TNB 17例。通过外周静脉血提取基因组DNA，对BRCA1/2 基因的全部编码序列进行扩增。用高效液相色谱分析...
Brca2 C-terminus interacts with Rad51 and contributes to nuclear focus formation in double-strand break repair of DNA
Brca2 C-terminus interacts Rad51 double-strand break repair of DNA
2009/3/3
In humans and mice, the interaction between the breast cancer susceptibility protein, BRCA2, and RAD51 recombinase is essential for DNA repair by homologous recombination, the failure of this process ...
Insertion/deletion polymorphism in the BRCA2 nuclear localization signal
Insertion/deletion polymorphism BRCA2 nuclear localization signal
2009/3/2
Mutations in human BRCA2 confer an increased risk of female breast cancer. In this study, we found a novel insertion/deletion polymorphism (10204insAAA causing amino acid change M3332IK) in canine B...
遗传性乳腺卵巢癌易感基因BRCA1 ,BRCA2 均为经典的抑癌基因,其产物对细胞生长增殖起负调控作用,其结构和功能的异常是细胞恶变的一种重要原因。近年来的研究表明BRCA1、BRCA2 等乳腺卵巢癌易感基因在遗传性乳腺卵巢癌综合征发生的过程中起重要的作用。对这些基因的深入研究将对遗传性乳腺卵巢癌综合征的发生机制的阐明、早期诊断及治疗有着重要的理论意义和实际应用价值。本文就遗传性乳腺卵巢癌易感基因...