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Total Synthesis of (±)-Decursivine and (±)-Serotobenine: A Witkop Photocyclization/Elimination/O-Michael Addition Cascade Approach
Total Synthesis of (±) Decursivine and (±)-Serotobenine A Witkop Photocyclization/Elimination/O-Michael Addition Cascade Approach
2012/7/3
Decursivine和Serotobenine是一类具有苯并二氢呋喃,吲哚并八元内酰胺多环体系的吲哚生物碱,分别具有抗疟疾及广泛的抗菌活性,其良好的生物活性和独特新颖的结构,引起了合成化学家的关注。其中Michael A. Kerr小组以18步3%的总收率首次完成了(±)-Decursivine的全合成,Tohru Fukuyama小组以24步8%的总收率首次完成了(-)-Serotobenin...