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Molecular Biology of Polyketide Biosynthesis
polyketides biosynthetic pathway engineering Streptomyces rimosus oxytetracycline
2009/3/20
Streptomyces species and related genera synthesize a large number of secondary metabolites, many of which are biologically active. Amongst them, polyketides is the largest class. Polyketides are a str...
Exploring Protein Interactions on a Minimal Type II Polyketide Synthase Using a Yeast Two-Hybrid System
Streptomyces aromatic polyketides protein interactions
2009/3/16
Interactions between proteins that form the ’minimal’ type II polyketide synthase in the doxorubicin producing biosynthetic pathway from Streptomyces peucetius were investigated using a yeast two-hybr...
Rational Design of Polyketide Natural Products
polyketide biosynthetic engineering erythromycin
2009/3/16
Compounds of polyketide origin possess a wealth of pharmacological effects, including antibacterial, antifungal, antiparasitic, anticancer and immunosuppressive activities. Many of these compounds and...