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引导编辑系统（Prime editor, PE）作为目前应用灵活、前景广阔的新型基因组编辑工具，可以实现植物基因组任意碱基的替换以及小片段的插入和删除，并在与位点特异性重组酶耦合时展现出高效精准大片段定点插入的潜力。由于PE在植物中的编辑效率偏低，目前虽有多项研究通过不同策略来提升植物引导编辑系统的效率，但这些改进的引导编辑器依然存在位点偏好明显、普适性较差等问题，并且大多数优化集中在水稻和玉米等...
南京农业大学农学院《Nature Communications》发表万建民院士团队“Genome-Wide association studies identify OsWRKY53 as s key regulator of salt tolerance in rice”（图）
万建民 基因 分子机制 蛋白
2023/10/28
盐碱胁迫影响水稻的生长发育、存活率与最终产量。水稻耐盐碱是由多基因控制的复杂性状。研究水稻应对盐碱胁迫的关键基因及其调控网络，对于培育耐盐碱水稻品种具有重要科学意义和应用价值。2023年6月16日，国际著名期刊Nature Communications发表了万建民院士团队在水稻耐盐碱研究上的新进展。
The liver’s ability to regenerate itself is legendary. Even if more than 70 percent of the organ is removed, the remaining tissue can regrow an entire new liver.
In Down syndrome cells, genome-wide disruptions mimic a senescence-like state（图）
唐氏综合症 细胞生物学 全基因组 破坏模仿 衰老样状态
2023/6/6
In Down syndrome, the third copy of chromosome 21 causes a reorganization of the 3D configuration of the entire genome in a key cell type of the developing brain, a new study shows. The resulting disr...
Genome-wide identification of NF-YA gene family in cotton and the positive role of GhNF-YA10 and GhNF-YA23 in salt tolerance
全基因组分析 雷蒙德氏棉 亚洲棉 海岛棉 陆地棉
2024/5/17
本研究基于全基因组分析，在雷蒙德氏棉、亚洲棉、海岛棉和陆地棉基因组中分别鉴定得到16、16、31和29个NF-YA基因。通过进化树分析将NF-YA基因分为4个亚组。结构分析表明NF-YA基因在棉属进化过程中相对保守。荧光定量显示GhNF-YAs可能通过ABA和 MeJA的调控通路响应盐和干旱。VIGS沉默GhNF-YA10和GhNF-YA23的表达，能显著降低棉花对盐的抗性，表明这两个基...
2021年5月3日，中国农业大学生物学院生物学院吴森课题组在Genome Research杂志上在线发表了题为“A HIT-trapping strategy for rapid generation of reversible and conditional alleles using a universal donor” 的研究论文。报道了一种新的基因定点突变策略，为规模化制备哺乳动物尤其是大...
Nature-inspired CRISPR enzymes for expansive genome editing（图）
CRISPR酶 基因组编辑 应用计算生物学 DNA序列
2023/6/19
In nature, bacteria use CRISPR as an adaptive immune system to protect themselves against viruses. Over the past decade, scientists have been able to successfully build upon that natural phenomenon wi...
Guacamole lovers,rejoice! The avocado genome has been sequenced（图）
Guacamole lovers avocado genome sequenced
2019/10/21
We now know the DNA of guacamole.Scientists have sequenced the avocado genome, shedding light on the ancient origins of this buttery fruit and laying the groundwork for future improvements to farming....
Researchers wirelessly manipulate gene, step toward reprogramming the human genome（图）
manipulate gene toward reprogramming human genome
2019/10/23
A new University at Buffalo-led study supported by NSF describes how researchers wirelessly controlled FGFR1 -- a gene that plays a key role in how animals grow from embryos to adults -- in lab-grown ...
2018年冷泉港亚洲会议：Systems Biology of Gene Regulation&Genome Editing（Cold Spring Harbor Asia conference on Systems Biology of Gene Regulation & Genome Editing）
2018年 冷泉港亚洲会议 Systems Biology of Gene Regulation&Genome Editing
2018/1/12
We are pleased to announce the Cold Spring Harbor Asia conference on Systems Biology of Gene Regulation & Genome Editing which will be held in Suzhou, China, located approximately 60 miles west of Sha...
2018年冷泉港亚洲会议：Genome Editing:All Things Considered
2018年 冷泉港亚洲会议 Genome Editing:All Things Considered
2018/1/12
We are pleased to announce the Cold Spring Harbor Asia conference on Genome Editing: All Things Considered which will be held in Suzhou, China, located approximately 60 miles west of Shanghai. The con...
Tricky grass genome sequenced after two decades of investment and research（图）
Tricky grass genome sequenced after two decades investment research
2017/12/19
Imagine if as you read this article, blocks of text kept rearranging themselves, recombining and repeating, seemingly at random. Now imagine those blocks of text are genes. You might have some idea of...
Detailed new ‘reference’ genome for maize shows the plant has deep resources for continued adaptation
reference genome maize deep resources continued adaptation
2017/7/21
A new, much more detailed reference genome for maize, or corn, as it is called in the U.S., will be published in Nature today. In its accounting of the sequence of DNA letters in the plant’s...
Garden lettuce, or Lactuca sativa, is the plant species that includes a salad bar’s worth of lettuce types, ranging from iceberg to romaine. With an annual on-farm value of more than $2.4 billion, it ...
“Smart” Cephalopods Trade Off Genome Evolution for Prolific RNA Editing
Smart Cephalopods Trade Off Genome Evolution Prolific RNA Editing
2017/4/27
Octopus, squid, and cuttlefish are famous for engaging in complex behavior, from unlocking an aquarium tank and escaping to instantaneous skin camouflage to hide from predators. A new study suggests t...