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Notch is crucial for multiple stages of T cell development, including the CD4+CD8+ double positive (DP) to CD8 + single positive (SP) transition, but regulation of Notch activation is not well underst...
The cytokine IFN-γ is important in mediating immune responses, while the Notch family of transmembrane receptors has been implicated in modulating T cell differentiation at several stages of developme...
The epidermal growth factor receptor (EGFR) plays important roles in the control of many fundamental cellular processes including cell cycle, cell migration, cell metabolism and survival, cell prolife...
Notch1 specifically upregulates expression of the cytokine interferon in peripheral T cells through activation of NF-κB. However, how Notch mediates NF-κB activation remains unclear. NF-κB activatio...
Workshop cluster 1 (WC1) molecules are exclusively expressed on the surface of γδ T cells. They belong to the scavenger receptor cysteine-rich (SRCR) superfamily and are encoded by a multiple-gene fam...
Cleavage of the Notch receptor via a γ-secretase, results in the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-JΚ, resulting in the activatio...
o better understand the pathophysiological role of Src protein, a non-receptor protein tyrosine kinase of 60 kDa, in the ischemic brain, we investigated the time course and regional distribution of a...
Aims/hypothesis. The mechanisms by which glucose injures cells of the cardiovascular system include gen-eration of reactive oxygen species and induction of cellular apoptosis. To date, little is kno...

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