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Regulation of the p53 tumor suppressor gene in the mammary gland and its role in tumorigenesis
Biological sciences p53 Tumor suppressor Mammary gland Tumorigenesis
2015/1/28
Breast cancer is the most frequent tumor type among women. Heightened susceptibility of the breast to tumor development has been associated with early menarche, nulliparity, exposures to ionizing radi...
Alternative splicing of MDM2 during breast tumorigenesis and mammary gland *development
Genes proliferation cell cycle growth abnormal genes oncogenes and tumor suppressor protein and tumor
2014/12/11
The regulation of genes involved in proliferation and cell cycle control plays a critical role in normal development and differentiation. Aberrant expression of genes promoting proliferation (oncogene...
The role of ovarian hormones in p53-mediated resistance to mammary tumorigenesis
Pregnant breast cancer rodents estrogen and progestogen therapy breast cancer the incidence of a disease
2014/12/11
A full term pregnancy reduces breast cancer by up to 50%. In rodents, pregnancy or treatment with estrogen and progesterone to mimic pregnancy reduces mammary tumor incidence. The molecular mechanisms...