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Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment
ERC1 GRIN2A SRPX2
2017/8/25
A significant proportion of children have unexplained problems acquiring proficient linguistic skills despite adequate intelligence and opportunity. Developmental language disorders are highly heritab...
A common variant of the CNTNAP2 gene is associated with structural variation in the left superior occipital gyrus
CNTNAP2 Dorsal visual stream FOXP2 Grey matter Language VBM
2016/5/3
The CNTNAP2 gene encodes a cell-adhesion molecule that influences the properties of neural networks and the morphology and density of neurons and glial cells. Previous studies have shown association o...
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
Meta-analysis gene environment wide association scans accounting education level identifies additional loci refractive error
2016/5/3
Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the ...
Early developmental gene enhancers affect subcortical volumes in the adult human brain
functional genomics gene enhancer GWAS hippocampus neurodevelopment subcortical volume
2016/5/3
Genome-wide association screens aim to identify common genetic variants contributing to the phenotypic variability of complex traits, such as human height or brain morphology. The identified genetic v...
Lateralization of gene expression in human language cortex
Lateralization Gene expression
2015/12/18
Lateralization is an important aspect of the functional brain architecture for language and
other cognitive faculties. The molecular genetic basis of human brain lateralization is
unknown, and recen...
Exploring the Boundaries:Gene and Protein Identification in Biomedical Text
Gene and Protein Identification Biomedical Text
2015/6/12
We present a maximum-entropy based system incorporating a diverse set of features for identifying genes and proteins in biomedical abstracts. This system was entered in the BioCreative comparative eva...
Exploring the boundaries:gene and protein identification in biomedical text
Exploring the boundaries gene and protein biomedical text
2015/6/12
Background: Good automatic information extraction tools offer hope for automatic processing of the exploding biomedical literature, and successful named entity recognition is a key component for such ...
Assessing the effects of common variation in the FOXP2 gene on human brain structure
FOXP2 imaging genetics language transcription factor MRI brain anatomy VBM
2015/5/5
The FOXP2 transcription factor is one of the most well-known genes to have been implicated in developmental speech and language disorders. Rare mutations disrupting the function of this gene have been...
A direct molecular link between the autism candidate gene RORa and the schizophrenia candidate MIR137
direct molecular link autism candidate gene RORa the schizophrenia candidate MIR137
2015/5/5
Retinoic acid-related orphan receptor alpha gene (RORa) and the microRNA MIR137 have both recently been identified as novel candidate genes for neuropsychiatric disorders. RORa encodes a ligand-depend...