搜索结果: 1-15 共查到“知识库 Discovery”相关记录232条 . 查询时间(0.06 秒)
A novel tissue-engineered 3D tumor model for anti-cancer drug discovery
decellularized porcine lung matrix breast tumor model biocompatibility CARS drug resistance
2023/3/1
Cancer biology and drug discovery are heavily dependent on conventional 2D cell culture systems. However, a 2D culture is significantly limited by its ability to reflect 'true biology' of tumor in viv...
新冠奥密克戎突变株自2021年11月发现后，传播迅速，一个月内就成为了世界主要流行毒株，目前已进化出许多分支亚型，比如BA.2, BA4, BA.5等。由于奥密克戎突变株及其亚型对大多数新冠病毒中和抗体，包括许多处于临床阶段的中和抗体药物，产生免疫逃逸，因此，亟需开发出对奥密克戎突变株及其亚型具有广谱中和活性的抗体药物。
PTEN是一个关键的抑癌基因，其蛋白在肿瘤中经常发生缺失。PTEN蛋白的缺失可由遗传学和表观遗传学因素导致，但在肿瘤中PTEN蛋白的缺失比例常常比其基因突变、缺失比例要高很多，因此PTEN蛋白的降解成为肿瘤中研究的一个热点问题。以往研究发现，PTEN蛋白可受到多种翻译后修饰并转移到蛋白酶体进行降解，也有少量研究发现PTEN可经由溶酶体途径降解，但PTEN溶酶体降解的具体分子机制尚不清楚。
在真核生物中，三种结构保守的RNA聚合酶（Pol I，Pol II和Pol III）分别介导不同基因的转录，合成不同类型的RNA。其中Pol I定位在细胞核核仁中，主要转录rRNA，其转录活动可达整个胞内转录活动的60%，对于核糖体合成至关重要。临床研究证明，Pol I的突变会导致特雷彻·柯林斯综合征、面骨发育不全以及严重神经变性等疾病的发生，此外Pol I转录机制被认为是重要的抗癌治疗的药物靶点...
上海市免疫学研究所王锋团队Cell Discovery发文揭示COVID-19康复患者中T细胞受体组库和T细胞功能的动态变化机制（图）
COVID-19 上海市免疫学研究所 T细胞功能 呼吸系统
2023/4/13
2021年9月28日，上海交通大学医学院上海市免疫学研究所王锋课题组在国际期刊Cell Discovery在线发表了题为“Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals”的研究论文，揭示COVID-19康复患者出院时间点TCR组库多样性有所增加，但在痊愈1周之后恢复到基础水平，并...
浙江大学生命科学研究院2021年8月17日宋海卫和黄俊课题组在Cell Discovery上合作发表论文解析了INTS3/INTS6蛋白质复合物参与DNA损伤修复的分子与结构基础（图）
宋海卫 黄俊 蛋白质复合物 基因
2022/10/25
2021年8月17日，浙江大学生命科学研究院宋海卫课题组和黄俊课题组合作在Cell Discovery上发表了题为“Crystal structure of the INTS3/INTS6 complex reveals the functional importance of INTS3 dimerization in DSB repair”的研究论文。该论文在分子水平上揭示了INTS3的二聚化...
2020年10月27日，上海交通大学医学院上海市免疫学研究所叶菱秀研究团队在Cell Discovery杂志发表了题为“Sensitivity and specificity of SARS-CoV-2 S1 subunit in COVID-19 serology assays”的研究论文。该研究指出，SARS-CoV-2 S蛋白S1亚单位用于检测COVID-19抗体，具有良好敏感性和特异性，可...
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Structure Mpro SARS-CoV-2 discovery inhibitors
2020/6/12
A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of coronavirus disease 2019 (...
Mobile Private Contact Discovery at Scale
Private Contact Discovery Private Set Intersection Oblivious Pseudorandom Function
2019/5/21
Mobile messengers like WhatsApp perform contact discovery by uploading the user's entire address book to the service provider. This allows the service provider to determine which of the user's contact...
BIM-GIS ORIENTED INTELLIGENT KNOWLEDGE DISCOVERY
Smart City Knowledge discovery BIM GIS Fuzzy Reasoning Rules Extraction
2018/11/9
Urban and population growth results in increasing pressure on the public utilities like transport, energy, healthcare services, crime management and emergency services in the realm of smart city manag...
An important initialization step in many social-networking applications is contact discovery, which allows a user of the service to identify which of its existing social contacts also use the service....
Discovery and significance of Quaternary aqueously deposited aeolian sandstones in the Sanhu area, Qaidam Basin, China
Qaidam Basin Qigequan Formation Aqueously deposited Aeolian sandstones Paleoclimate
2018/4/2
Influenced by neo-tectonic movement, the Sanhu area of China’s Qaidam Basin formed in the Quaternary in response to migration of its depocentre. A study of core material from the Qijia 1 Well reveals ...
Higgs Discovery and the Look Elsewhere Effect
Higgs particle discovery condition Bayesianism 5 sigma limit collider physics
2016/6/12
The discovery of the Higgs particle required a signal of five sigma significance. The rigid application of that condition is a convention that disregards more specific aspects of the given experiment....
Discovery of New Ligand Binding Pathways in Myoglobin by Random Mutagenesis
Animals Whales Myoglobin Ligands Genetic Techniques Mutagenesis Binding Sites Amino Acid Sequence Protein Conformation Structure-Activity Relationship
2016/5/23
A random library of single amino acid mutants of myoglobin was generated using a highly efficient, single-base-misincorporation random mutagenesis method to discover new ligand-binding pathways in myo...
Discovery of Gene Sources for Economic Traits in Hanwoo by Whole-genome Resequencing
Single Nucleotide Polymorphism [SNP] Next Generation Sequencing Quantitative Trait Locus Hanwoo
2016/11/10
Hanwoo, a Korean native cattle (Bos taurus coreana), has great economic value due to high meat quality. Also, the breed has genetic variations that are associated with production traits such as health...