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Direct and indirect effects of murine interleukin-2, gamma interferon, and tumor necrosis factor on testosterone synthesis in mouse Leydig cells
murine interleukin-2 gamma interferon tumor necrosis factor testosterone synthesis
2009/2/11
It was recently observed that treatment of patients with a high dosage of human interleukin (IL-2) resulted in suppression of plasma concentrations of testosterone. A murine model was developed to a...
Regulation of testosterone production in the adjuvant-induced arthritic rat
testosterone production adjuvant-induced arthritic rat
2009/2/10
Serum testosterone concentrations are reduced in men with rheumatoid arthritis and in rats with adjuvant-induced arthritis, a common model for rheumatoid arthritis. To understand the mechanism res...
Response of prostate volume, prostate-specific antigen, and testosterone to flutamide in men with benign prostatic hyperplasia
Treatment benign prostatic hyperplasia flutamide
2009/2/7
Patients diagnosed as having benign prostatic hyperplasia (BPH) had determination of prostate volume (PV), prostate-specific antigen (PSA), and serum testosterone before consideration for entry into...
Effects of follicular fluid administration on serum bioactive and immunoreactive FSH concentrations and compensatory testosterone secretion in hemicastrated adult rats
Rat hemicastration follicle-stimulating hormone(FSH) testosterone inhibin
2009/2/7
In adult rats, removal of one testis (hemicastration) results in an elevation of serum follicle-stimulating hormone (FSH) concentrations and a compensation in testosterone secretion by the remain...
Diurnal rhythm of testosterone and luteinizing hormone in hypogonadal men
Diurnal rhythm of testosterone luteinizing hormone hypogonadal men
2009/2/7
To determine the relationship between increasing luteinizing hormone (LH) production and the diurnal secretion of LH and testosterone (T) in adult men, studies were performed on five men with gonado...
Extracellular calcium and luteinizing hormone effects on 22-hydroxycholesterol used for testosterone production in mouse Leydig cells
Extracellular calcium luteinizing hormone testosterone production mouse Leydig cells
2009/2/7
The effect of extracellular calcium on testosterone synthesis in response to luteinizing hormone (LH) or 22-hydroxycholesterol (22-OH-C) by isolated adult mouse Leydig cells was studied. Leydig ce...
Does gonadotropin receptor complex have an amplifying role in cAMP/testosterone production in Leydig cells?
Human chorionic gonadotropin (hCG) luteinizing hormone (LH) Leydig cell purification testis
2009/2/7
The dose-response relationship between luteinizing hormone/human chorionic gonadotropin (LH/hCG)-stimulated biological response and 125I-labeled hCG binding was studied in purified Leydig cells from...
Quantitative maintenance of spermatogenesis in cyclosporine-treated rats by exogenous administration of testosterone propionate
Testosterone cyclosporine spermatogenesis
2009/2/6
The authors had previously shown that the subcutaneous administration of cyclosporine (CsA) resulted in an impairment of spermatogenesis. Testosterone levels declined and gonadotropin levels increas...
Plasma levels of estradiol, testosterone, and DHEAS do not predict risk of coronary artery disease in men
estrogens androgens aging cardiovascular disease cardiovascular risk factors
2009/2/6
Prior studies have reported men with coronary artery disease (CAD) to have elevated plasma levels of estrogens and reduced concentrations of dehydroepiandrosterone (DHEA) or DHEA-sulfate (DHEAS). ...
Tumor necrosis factor and interleukin-1 stimulate testosterone secretion in adult male rat Leydig cells in vitro
umor necrosis factor interleukin-1 testis testosterone
2009/2/6
The actions of two cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), on testosterone production by dispersed adult testis cells and purified Leydig cells in culture were studied. In o...
Aromatase inhibitors in infertile patients:effects on seminal parameters,serum and seminal plasma testosterone levels,and estradiol levels during short-term follow-up
Male infertility estradiol testosterone aromatase inhibitors
2010/1/12
Aim: To evaluate the effects of an aromatase inhibitor (anastrozole) on seminal parameters, and on serum and seminal plasma testosterone/estradiol ratios in infertile patients, as well as to clarify i...
Testosterone release from a subcutaneous, biodegradable microcapsule formulation（Viatrel）in hypogonadal men
Hypogonadism poly-lactide-co-glycolide pharmacokinetics
2008/12/30
Men with hypogonadism require testosterone replacement for optimal health. In the United States, testosterone is currently administered by daily transdermal patches, topical gels or intramuscular in...
Daily testosterone and gonadotropin levels are similar in azoospermic and nonazoospermic normal men administered weekly testosterone: implications for male contraceptive development
Contraception gonadotropins azoospermia
2008/12/29
Weekly intramuscular administration of testosterone esters such as testosterone enanthate (TE) suppresses gonadotropins and spermatogenesis and has been studied as a male contraceptive. For unknown ...
Mullerian inhibiting substance inhibits testosterone synthesis in adult rats
Anti-Mu llerian hormone primary Leydig cells
2008/12/29
Mullerian inhibiting substance (MIS) is a gonadal hormone that causes regression of the Mullerian ducts during male sexual differentiation. Postnatally, MIS inhibits the proliferation and differen...
Atrazine effects on testosterone levels and androgen-dependent reproductive organs in peripubertal male rats
testosterone levels androgen-dependent reproductive organs peripubertal male rats
2008/12/26
Previous studies have reported that atrazine, a widely used herbicide that selectively inhibits photosynthesis in broadleaf and grassy weeds, has adverse effects on reproductive function in the male, ...