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Intragastric administration of leucine or isoleucine lowers the blood glucose response to a mixed-nutrient drink by different mechanisms in healthy, lean volunteers
branched-chain amino acids energy intake food intake gastric emptying GIP GLP-1 glucagon gut hormones humans insulin
2018/12/18
Background: The branched-chain amino acids leucine and isoleucine lower blood glucose after oral glucose ingestion, and the intraduodenal infusion of leucine decreases energy intake in healthy, lean m...
104名藏族志愿者中细胞色素P450 2C19m1的基因多态性Cytochrome P450 2C19 Gene Polymorphism in 104 Chinese Zang Volunteers
2007/12/20
摘要细胞色素P450 2C19（CYP2C19）参与临床上许多重要药物的代谢。根据其代谢S－美芬妥英或其他CYP2C19底物的能力不同，有强代谢者（EMs）和弱代谢者（PMs）之分。PMs表型的频发率存在明显的种族差异。在本文中，我们主要报道了细胞色素P450 2C19 m1在中国藏族人群中的多态性分布。在104例无血缘关系藏族人群中，49人（47.1%）为CYP2C19野生型纯合子（wt/wt）...